A pilot, open labelled, randomised controlled trial of hypertonic saline nasal irrigation and gargling for the common cold

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Efficacy of daily hypertonic saline nasal irrigation among patients with sinusitis: a randomized controlled trial.

OBJECTIVES To test whether daily hypertonic saline nasal irrigation improves sinus symptoms and quality of life and decreases medication use in adult subjects with a history of sinusitis. STUDY DESIGN Randomized controlled trial. Experimental subjects used nasal irrigation daily for 6 months. POPULATION Seventy-six subjects from primary care (n=70) and otolaryngology (n=6) clinics with hist...

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Bronchiolitis is a common disorder in young children that often results in hospitalisation. Except for a possible effect of nebulised hypertonic saline (sodium chloride), no evidence-based therapy is available. This study investigated the efficacy of nebulised 3% and 6% hypertonic saline compared with 0.9% hypertonic saline in children hospitalised with viral bronchiolitis. In this multicentre,...

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The efficacy of hypertonic saline nasal irrigation for chronic sinonasal symptoms.

OBJECTIVE To assess quality of life (QOL) in patients with sinonasal symptoms in response to hypertonic saline nasal irrigation (HSNI), and to assess HSNI use patterns. STUDY DESIGN AND SETTING The study was an uncontrolled 12-month follow-up to a randomized controlled trial (RCT) and used HSNI in a community setting. We included 54 participants with recurrent or chronic sinonasal symptoms. F...

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Normal Saline vs. Hypertonic Saline Nebulization for Acute Bronchiolitis: A Randomized Clinical Trial

BackgroundWe aimed to compare the efficacy of nebulized hypertonic (3%, 5% and 7%) saline with normal saline in hospitalized infants with acute bronchiolitis.Materials and MethodsIn this triple-blinded randomized clinical trial, 120 children with moderate to severe bronchiolitis randomly assigned into four groups to receive nebulized normal saline (group A),  saline 3% (group B), saline 5% (gro...

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This randomized controlled trial compared 7% hypertonic saline versus 0.9% (normal) saline, in addition to racemic epinephrine (in both groups), among infants with mild to moderate severity bronchiolitis. The authors used a modification of the oft-applied bronchiolitis severity score (BSS) by Wang, et al. [1] to evaluate the efficacy of treatment at multiple time points until discharge/ disposi...

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ژورنال

عنوان ژورنال: Scientific Reports

سال: 2019

ISSN: 2045-2322

DOI: 10.1038/s41598-018-37703-3